The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database.

ABSTRACT:

Background

It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients.

Methods

Critically ill patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The duration and the magnitude of ECVP were calculated. Normalized ECVP load was defined as the ECVP load (the sum of ECVP value times its duration) divided by the total duration of ECVP. The primary endpoint was 28-day mortality. Kaplan-Meier survival analysis was used to compare survival between patients with high or low normalized ECVP load.

Results

A total of 1071 sepsis patients were included. Higher normalized ECVP load was associated with higher mortality

SUBMITTER: Chen H 

PROVIDER: S-EPMC9907836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature