Ontology highlight
ABSTRACT:
SUBMITTER: Han L
PROVIDER: S-EPMC9908026 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Han Lu L Luo Zhiteng Z Ju Yingchen Y Chen Bingyi B Zou Taotao T Wang Junjian J Xu Jun J Gu Qiong Q Yang Xiang-Lei XL Schimmel Paul P Zhou Huihao H
Science advances 20230208 6
As a class of essential enzymes in protein translation, aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are organized into two classes of 10 enzymes each, based on two conserved active site architectures. The (αβ)<sub>2</sub> glycyl-tRNA synthetase (GlyRS) in many bacteria is an orphan aaRS whose sequence and unprecedented X-shaped structure are distinct from those of all other aaRSs, including many other bacterial and all eukaryotic GlyRSs. Here, we report a cocrystal structure to elucidate h ...[more]