Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study.

ABSTRACT:

Background

Higher urate levels are associated with higher systolic blood pressure (SBP) in adults, and in pregnancy with lower offspring birthweight. Mendelian randomization (MR) analyses suggest a causal effect of higher urate on higher SBP and of higher maternal SBP on lower offspring birthweight. If urate causally reduces birthweight, it might confound the effect of SBP on birthweight. We therefore tested for a causal effect of maternal urate on offspring birthweight.

Methods

We tested the association between maternal urate levels and offspring birthweight using multivariable linear regression in the Exeter Family Study of Childhood Health (EFSOCH; n = 872) and UK Biobank (UKB; n = 133 187). We conducted two-sample MR to test for a causal effect of maternal urate [114 sin

SUBMITTER: Decina CS 

PROVIDER: S-EPMC9908052 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature