Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease.

ABSTRACT:

Background

The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy.

Methods

Using an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg of aspirin per day. The primary effectiveness outcome was a composite of death from any cause, hospitalization for myocardial infarction, or hospitalization for stroke, assessed in a time-to-event analysis. The primary safety outcome was hospitalization for major bleeding, also assessed in a time-to-event analysis.

Results

A total of 15,076 patients were followed for a median

SUBMITTER: Jones WS 

PROVIDER: S-EPMC9908069 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature