A RORγt⁺ cell instructs gut microbiota-specific T_reg cell differentiation.

ABSTRACT: The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment^1,2. The consequences of disturbing this balance include proximal inflammatory conditions, such as Crohn's disease, and systemic illnesses. This equilibrium is achieved in part through the induction of both effector and suppressor arms of the adaptive immune system. Helicobacter species induce T regulatory (T_reg) and T follicular helper (T_FH) cells under homeostatic conditions, but induce inflammatory T helper 17 (T_H17) cells when induced T_reg (iT_reg) cells are compromised^3,4. How Helicobacter and other gut

SUBMITTER: Kedmi R 

PROVIDER: S-EPMC9908423 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature