Integrative analyses reveal prognostic and immunogenic characteristics of m7G methylation regulators in patients with glioma.

ABSTRACT:

Objectives

The expression profiles, biological mechanisms, and clinical relevance of m7G regulators in glioma were studied in this research.

Methods

Based on the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets, glioma patients, can be categorized into three groups according to 29 m7G regulators, and different subtypes of glioma show different immune cell infiltration characteristics, function enrichment, and clinical prognosis. Three gene clusters were confirmed by utilizing the differentially expressed genes (DEGs) across the three m7G clusters.

Results

A prognostic signature based on 12 m7G regulators was established and validated, producing an effective tool for predicting overall survival (OS) in glioma patients. High m7G scores indi

SUBMITTER: Tang L 

PROVIDER: S-EPMC9908444 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature