PTTG1IP (PBF) is a prognostic marker and correlates with immune infiltrate in ovarian cancer.

ABSTRACT:

Objective

An oncogenic protein, pituitary tumor transforming gene 1 binding factor (PTTG1IP, also called PBF), has been found to be expressed in various cancers. However, few studies have explored its prognostic significance and biologic function in epithelial ovarian cancer (EOC).

Methods

Based on the Cancer Genome Atlas (TCGA) database, this study determined the differential expression of PBF at the mRNA level in EOC and normal tissues, which was then verified using real-time PCR and western blotting. Moreover, the Kaplan-Meier method and the Cox regression method were adopted to assess the clinical value of PBF in EOC. A nomogram model was constructed to evaluate the prognostic performance of PBF in EOC. Gene set enrichment analysis (GSEA) was employed to evaluate the sig

SUBMITTER: Ma R 

PROVIDER: S-EPMC9908464 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature