Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy.

ABSTRACT:

Objective

The purpose of this study was to evaluate the influence of abnormal semen parameters on embryo aneuploidy based on single nucleotide polymorphism microarray (SNP array).

Methods

A total of 464 blastocysts from 103 PGT-A cycles were analyzed. The embryo quality and embryo aneuploidy rates were compared between different groups which divided by male semen parameters (sperm concentration, motility, morphology, and DFI) according the WHO criteria (2021).

Results

The total blastocysts chromosome aneuploidy rate was 42.3% (191/452). In the teratozoospermia group, the good-quality embryo and blastocyst formation rate were lower than the normal group(44.4% vs 60.7%, P <0.01; 33.3% vs 43.5%, P <0.05), The good-quality embryo rate in normal DFI group was significantly

SUBMITTER: Yang H 

PROVIDER: S-EPMC9908608 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature