Weekly somapacitan had no adverse effects on glucose metabolism in adults with growth hormone deficiency.

ABSTRACT:

Purpose

The long-term effects of long-acting growth hormone (LAGH) analogues on glucose metabolism in adult growth hormone deficiency (AGHD) are not known. We investigated the impact of LAGH somapacitan, administered once-weekly, on glucose metabolism in patients with AGHD.

Methods

In post hoc-defined analyses, we compared the effects of somapacitan with daily growth hormone (GH) and placebo on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) in patients with AGHD across a unique data set from three phase 3 randomized controlled trials (REAL 1, REAL 2 and REAL Japan).

Results

No new cases of diabetes mellitus were reported with somapacitan. Among GH-

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC9908671 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature