Intraperitoneal Chemotherapy for Unresectable Peritoneal Surface Malignancies.

ABSTRACT: Malignancies of the peritoneal cavity are associated with a dismal prognosis. Systemic chemotherapy is the gold standard for patients with unresectable peritoneal disease, but its intraperitoneal effect is hampered by the peritoneal-plasma barrier. Intraperitoneal chemotherapy, which is administered repeatedly into the peritoneal cavity through a peritoneal implanted port, could provide a novel treatment modality for this patient population. This review provides a systematic overview of intraperitoneal used drugs, the performed clinical studies so far, and the complications of the peritoneal implemental ports. Several anticancer drugs have been studied for intraperitoneal application, with the taxanes paclitaxel and docetaxel as the most commonly used drug. Repeated intraperitoneal chemoth

SUBMITTER: Guchelaar NAD 

PROVIDER: S-EPMC9908703 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature