Sodium aescinate inhibits microglia activation through NF-κB pathway and exerts neuroprotective effect.

ABSTRACT: Background: Microglia are resident immune cells of the central nervous system that sense environmental changes and maintain central nervous system homeostasis. Dysfunctional microglia produce toxic mediators that lead to neuronal death. Recent studies suggest that Sodium Aescinate has a neuroprotective effect. However, it is unclear whether Sodium Aescinate exerts neuroprotective effects by inhibiting activation of microglia. Method: Traumatic brain injury and lipopolysaccharide neuroinflammation model were used to evaluate the microglia activation in vivo. BV2 and primary microglia cells were used to assess the microglia activation in vitro. Molecular docking technique was used to predict the binding energy of Sodium Aescinate to NF-κB signaling pathway protein

SUBMITTER: Xu F 

PROVIDER: S-EPMC9908748 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature