Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies.

ABSTRACT:

Background

Orthohantaviruses are rodent-borne emerging viruses that cause haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome in America. Transmission between humans have been reported and the case-fatality rate ranges from 0.4% to 40% depending on virus strain. There is no specific and efficient treatment for patients with severe HFRS. Here, we characterised a fatal case of HFRS and sequenced the causing Puumala orthohantavirus (PUUV).

Methods

PUUV RNA and virus specific neutralising antibodies were quantified in plasma samples from the fatal case and other patients with non-fatal PUUV infection. To investigate if the causing PUUV strain was different from previously known strains, Sanger sequencing was performed directly from the pati

SUBMITTER: Tuiskunen Back A 

PROVIDER: S-EPMC9908776 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature