Genetic differences between suicide deaths and deaths of undetermined intent.

ABSTRACT:

Introduction

Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology.

Methods

The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes.

Results

In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to unambiguous suicide (OR = 0.91-0.95), while t

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC9908835 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature