Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations.

ABSTRACT: Immune cell function is critically dependent on precise control over transcriptional output from the genome. In this respect, integration of environmental signals that regulate gene expression, specifically by transcription factors, enhancer DNA elements, genome topography and non-coding RNAs (ncRNAs), are key components. The first three have been extensively investigated. Even though non-coding RNAs represent the vast majority of cellular RNA species, this class of RNA remains historically understudied. This is partly because of a lag in technological and bioinformatic innovations specifically capable of identifying and accurately measuring their expression. Nevertheless, recent progress in this domain has enabled a profusion of publications identifying novel sub-types of ncRNAs and studi

SUBMITTER: Kumar D 

PROVIDER: S-EPMC9908861 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature