Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides.

ABSTRACT: Biological systems respond to environmental perturbations and a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. Experimental information from transcriptomic studies has allowed the identification of gene networks that contribute to our understanding of microbial adaptations. In this study, we analyzed the gene co-expression networks of three Bifidobacterium species in response to different types of human milk oligosaccharides (HMO) using weighted gene co-expression analysis (WGCNA). RNA-seq data obtained from Geo Datasets were obtained for Bifidobacterium longum subsp. Infantis, Bifidobacterium bifidum and Bifidobacterium longum subsp. Longum. Between 10 and 20 co-expressing modules were obtained for each dataset. HMO-asso

SUBMITTER: Gonzalez-Morelo KJ 

PROVIDER: S-EPMC9908966 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature