Molecular evolution and population genetics of glutamate decarboxylase acid resistance pathway in lactic acid bacteria.

ABSTRACT: Glutamate decarboxylase (GAD) pathway (GDP) is a major acid resistance mechanism enabling microorganisms' survival in low pH environments. We aimed to study the molecular evolution and population genetics of GDP in Lactic Acid Bacteria (LAB) to understand evolutionary processes shaping adaptation to acidic environments comparing species where the GDP genes are organized in an operon structure (Levilactobacillus brevis) versus lack of an operon structure (Lactiplantibacillus plantarum). Within species molecular population genetic analyses of GDP genes in L. brevis and L. plantarum sampled from diverse fermented food and other environments showed abundant synonymous and non-synonymous nucleotide diversity, mostly driven by low frequency changes, distributed throug

SUBMITTER: Sezgin E 

PROVIDER: S-EPMC9909107 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature