Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive and Lphn3 knockout rats.

ABSTRACT:

Introduction

Impulsivity is a symptom of attention-deficit/hyperactivity disorder (ADHD) and variants in the Lphn3 (Adgrl3) gene (OMIM 616417) have been linked to ADHD. This project utilized a delay-discounting (DD) task to examine the impact of Lphn3 deletion in rats on impulsive choice. "Positive control" measures were also collected in spontaneously hypertensive rats (SHRs), another animal model of ADHD.

Methods

For Experiment I, rats were given the option to press one lever for a delayed reward of 3 food pellets or the other lever for an immediate reward of 1 pellet. Impulsive choice was measured as the tendency to discount the larger, delayed reward. We hypothesized that impulsive choice would be greater in the SHR and Lphn3 knockout (KO) rats relat

SUBMITTER: Carbajal MS 

PROVIDER: S-EPMC9909198 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature