Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder.

ABSTRACT:

Background

This study aimed to investigate the relationships between regional neural activity and multiple related indicators in patients with major depressive disorder (MDD).

Methods

Forty-two patients and 42 healthy controls (HCs) were enrolled. Pearson/Spearman correlation analyses were applied to examine the associations between abnormal regional homogeneity (ReHo) and different indicators in the patients.

Results

Compared with HCs, patients with MDD had increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo values in the left putamen, anterior cingulate cortex (ACC), and precentral gyrus. The ReHo of the left putamen was positively correlated with the PR interval, Repeatable Battery for the Assessment of Neuropsychological Status 4A, and Disc

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9909210 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature