In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes.

ABSTRACT:

Background

Critically ill patients routinely receive antibiotics with activity against anaerobic gut bacteria. However, in other disease states and animal models, gut anaerobes are protective against pneumonia, organ failure and mortality. We therefore designed a translational series of analyses and experiments to determine the effects of anti-anaerobic antibiotics on the risk of adverse clinical outcomes among critically ill patients.

Methods

We conducted a retrospective single-centre cohort study of 3032 critically ill patients, comparing patients who did and did not receive early anti-anaerobic antibiotics. We compared intensive care unit outcomes (ventilator-associated pneumonia (VAP)-free survival, infection-free survival and overall survival) in all patients and change

SUBMITTER: Chanderraj R 

PROVIDER: S-EPMC9909213 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature