Induction of autophagy improves skin and hair conditions in dogs with underlying diseases.

ABSTRACT:

Background

Autophagy was reported to play a crucial role in maintaining general and skin health.

Methods

The study used a synthesized autophagy inducer (AI) (Aquatide™ cospharm Inc.; Daejeon, Korea), for evaluating the effects of autophagy on skin and hair in dogs. Twenty-two dogs with poor skin and hair which were diagnosed with canine atopic dermatitis (CAD) or pituitary-dependent hyperadrenocorticism (PDH) were included. Clinical scores using Canine Atopic Dermatitis Extent and Severity Index-04 (CADESI-04), Pruritus Visual Analog Scale (PVAS) and skin barrier function using measurement of transepidermal water loss (TEWL) were evaluated and canine keratinocytes were also used in vitro investigation of pro-inflammatory cytokines after AI treatment.

Results

In

SUBMITTER: Kim Y 

PROVIDER: S-EPMC9909349 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature