An adaptive and versatile method to quantitate and characterize collective cell migration behaviors on complex surfaces.

ABSTRACT: Collective cell migration is critical for proper embryonic development, wound healing, and cancer cell invasion. However, much of our knowledge of cell migration has been performed using flat surfaces that lack topographical features and do not recapitulate the complex fibrous architecture of the extracellular matrix (ECM). The recent availability of synthetic fibrous networks designed to mimic in vivo ECM has been key to identify the topological features that dictate cell migration patterns as well as to determine the underlying mechanisms that regulate topography-sensing. Recent studies have underscored the prevalence of collective cell migration during cancer invasion, and these observations present a compelling need to understand the mechanisms controlling contact guidance withi

SUBMITTER: Loesel KE 

PROVIDER: S-EPMC9909417 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature