Novel diagnostic biomarkers related to immune infiltration in Parkinson's disease by bioinformatics analysis.

ABSTRACT:

Background

Parkinson's disease (PD) is Pengfei Zhang Liwen Zhao Pengfei Zhang Liwen Zhao a common neurological disorder involving a complex relationship with immune infiltration. Therefore, we aimed to explore PD immune infiltration patterns and identify novel immune-related diagnostic biomarkers.

Materials and methods

Three substantia nigra expression microarray datasets were integrated with elimination of batch effects. Differentially expressed genes (DEGs) were screened using the "limma" package, and functional enrichment was analyzed. Weighted gene co-expression network analysis (WGCNA) was performed to explore the key module most significantly associated with PD; the intersection of DEGs and the key module in WGCNA were considered common genes (CGs). The CG protein-prot

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9909419 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature