Association of Long-term Change in N-Terminal Pro-B-Type Natriuretic Peptide With Incident Heart Failure and Death.

ABSTRACT:

Importance

Most studies, especially in primary prevention patients, have evaluated N-terminal B-type natriuretic peptide (NT-proBNP) at one time point. Evaluation of change in NT-proBNP may improve risk stratification for incident cardiovascular events.

Objective

To assess the association between change in NT-proBNP and risk for incident heart failure (HF) and death.

Design, setting, and participants

Participants were recruited from 4 US communities enrolled in the Atherosclerosis Risk in Community (ARIC) study. Individuals who attended ARIC visits 2 and 4 (approximately 6 years apart) with measurements of NT-proBNP and without prevalent HF were included. Assays of NT-proBNP were conducted between 2011 and 2013, and analysis took place between July 2021 and October 20

SUBMITTER: Jia X 

PROVIDER: S-EPMC9909572 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature