Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction.

ABSTRACT:

Importance

The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4 receptor has been associated with improved learning and memory in healthy individuals.

Objective

To map the neurobiological signatures of patients with untreated MDD compared with healthy controls and to examine the association between cerebral 5-HT4 receptor binding and cognitive functions in the depressed state.

Design, setting, and participants

This case-control study used baseline data from the NeuroPharm clinical depression trial in Denmark. Adult participants included antidepressant-free outpatients with a current moderate to severe depressive episode and healthy controls. All participants

SUBMITTER: Kohler-Forsberg K 

PROVIDER: S-EPMC9909578 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature