Extensive accumulation of misfolded protein aggregates during natural aging and senescence.

ABSTRACT: Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, which are common also in natural aging. Thus, we hypothesized that aging is associated to the widespread and progressive misfolding and aggregation of many proteins in various tissues. In this study, we analyzed whether proteins misfold, aggregate, and accumulate during normal aging in three different biological systems, namely senescent cells, Caenorhabditis elegans, and mouse tissues collected at different times from youth to old age. Our results show a significant accumulation of misfolde

SUBMITTER: Cuanalo-Contreras K 

PROVIDER: S-EPMC9909609 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature