Human Satellite 1A analysis provides evidence of pericentromeric transcription.

ABSTRACT:

Background

Pericentromeric regions of human chromosomes are composed of tandem-repeated and highly organized sequences named satellite DNAs. Human classical satellite DNAs are classified into three families named HSat1, HSat2, and HSat3, which have historically posed a challenge for the assembly of the human reference genome where they are misrepresented due to their repetitive nature. Although being known for a long time as the most AT-rich fraction of the human genome, classical satellite HSat1A has been disregarded in genomic and transcriptional studies, falling behind other human satellites in terms of functional knowledge. Here, we aim to characterize and provide an understanding on the biological relevance of HSat1A.

Results

The path followed herein trails with HSat1A

SUBMITTER: Lopes M 

PROVIDER: S-EPMC9909926 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature