Intraoperative oxygen tension and redox homeostasis in Pseudomyxoma peritonei: A short case series.

ABSTRACT:

Introduction

Pseudomyxoma peritonei (PMP) is a rare malignant disease characterized by a massive multifocal accumulation of mucin within the peritoneal cavity. The current treatment option is based on complete cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy. However, the recurrence is frequent with subsequent progression and death. To date, most of the studies published in PMP are related to histological and genomic analyses. Thus, the need for further studies unveiling the underlying PMP molecular mechanisms is urgent. In this regard, hypoxia and oxidative stress have been extensively related to tumoral pathologies, although their contribution to PMP has not been elucidated.

Methods

In this manuscript, we have evaluated, for the first time, the

SUBMITTER: Valenzuela-Molina F 

PROVIDER: S-EPMC9909963 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature