M6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma.

ABSTRACT:

Background

Colonic adenocarcinoma (COAD) is a common gastrointestinal tract tumor, and its occurrence and progression are typically associated with genomic instability, tumor-suppressor gene and oncogene mutations, and tumor mutational load. N6-methyladenosine (m⁶A) modification of RNAs and long non-coding RNA (lncRNA) expression are important in tumorigenesis and progression. However, the regulatory roles of m⁶A-associated lncRNAs in the tumor microenvironment, stratification of prognosis, and immunotherapy are unclear.

Methods

We screened 43 prognostic lncRNAs linked to m⁶A and performed consistent molecular typing of COAD using consensus clustering. The single-sample Gene Set Enrichment Analysis and ESTIMATE algorithms were used to assess

SUBMITTER: Wang HL 

PROVIDER: S-EPMC9909974 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature