NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.

ABSTRACT: NLRP3 has been involved in several physiological and pathological processes. However, the role and mechanism of NLRP3 activation in mandibular healing remain unclear. Here, a full-thickness mandibular defect model by osteotomy was established in wild-type (WT) and Prx1-Cre/ROSA^nTnG mice to demonstrate the NLRP3 inflammasome activation in mandibular healing. We found that NLRP3 was activated in mesenchymal stem cells (MSCs)-mediated mandibular healing and was prominent in Prx1⁺ cells. Inhibition of NLRP3 exerted a positive effect on bone formation without changing the number of Prx1-cre⁺ cells in the defect areas. In addition, NLRP3 deficiency promoted osteoblast differentiation. We next screened for the deubiquitinating enzymes that were previously reported

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9910010 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature