Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic.

ABSTRACT: Targeted protein degradation is a rapidly exploding drug discovery strategy that uses small molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin-proteasome pathway. It shows great potential for treating diseases such as cancer and infectious, inflammatory, and neurodegenerative diseases, especially for those with "undruggable" pathogenic protein targets. With the recent rise of the "molecular glue" type of protein degraders, which tighten and simplify the connection of an E3 ligase with a disease-causing protein for ubiquitination and subsequent degradation, new therapies for unmet medical needs are being designed and developed. Here we use data from the CAS Content Collection and the publication landscape of recent research on targeted protein degra

SUBMITTER: Sasso JM 

PROVIDER: S-EPMC9910052 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature