Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients.

ABSTRACT: Human induced pluripotent stem cells (iPSCs) provide a virtually inexhaustible source of starting material for next generation cell therapies, offering new opportunities for regenerative medicine. Among different cell sources for the generation of iPSCs, urine cells are clinically relevant since these cells can be repeatedly obtained by non-invasive methods from patients of any age and health condition. These attributes encourage patients to participate in preclinical and clinical research. In particular, the use of urine-derived iPSC products is a convenient strategy for children with brain tumors, which are medically fragile patients. Here, we investigate the feasibility of using urine samples as a source of somatic cells to generate iPSC lines from pediatric patients with brain tumors (

SUBMITTER: Balina-Sanchez C 

PROVIDER: S-EPMC9910217 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature