Analysis of antiquorum-sensing and antibiofilm activity by pomelo peel extract (Citrus maxima) on multidrug-resistance Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is gram-negative bacteria with high adaptability by forming biofilms and quorum-sensing mechanisms to avoid immune responses and antimicrobial agents which tend to develop into Multidrug Resistance (MDR) related to Healthcare-Associated Infection (HAI) with a prevalence of 3,8% in Indonesia and a mortality of up to 69%. Polyphenol compounds found in pomelo peels (Citrus maxima) have been shown to have antibiofilm and antiquorum-sensing effects but are less investigated. Therefore, this study aimed to investigate those effects on MDR P. aeruginosa. In vitro study design is performed to evaluate the inhibition effect of ethanolic extract on bacterial growth (Kirby-Bauer test), biofilm formation (biofilm assay), and quorum-sensing activity (pyocyani

SUBMITTER: Sadeva IGKA 

PROVIDER: S-EPMC9910226 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature