A chiral magnetic molybdenum disulfide nanocomposite for direct enantioseparation of RS-propranolol.

ABSTRACT: We herein report a novel chiral magnetic molybdenum disulfide nanocomposite (MMoS₂/PNG-CD) with a high enantioselectivity and excellent thermosensitivity and magnetism. The prepared MMoS₂/PNG-CD shows temperature-dependent chiral discrimination and enantioselectivity toward a chiral drug RS-propranolol (RS-PPL), which is based on the molecular recognition ability of beta-cyclodextrin (β-CD) and the thermosensitivity of poly(N-isopropylacrylamide) (PNIPAM). The synthesized MMoS₂/PNG2-CD by using a monomer molar ratio of GMA to NIPAM of 2 : 1 demonstrates a high selectivity toward R-PPL over S-PPL due to the synergistic effect of the PNIPAM moieties and β-CD hosts. The thermo-induced volume phase transition (VPT) of the intr

SUBMITTER: Yu HR 

PROVIDER: S-EPMC9910328 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature