Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.

ABSTRACT: Transvection, a type of trans-regulation of gene expression in which regulatory elements on one chromosome influence elements on a paired homologous chromosome, is itself a complex biological phenotype subject to modification by genetic background effects. However, relatively few studies have explored how transvection is affected by distal genetic variation, perhaps because it is strongly influenced by local regulatory elements and chromosomal architecture. With the emergence of the "hub" model of transvection and a series of studies showing variation in transvection effects, it is becoming clear that genetic background plays an important role in how transvection influences gene transcription. We explored the effects of genetic background on transvection by performing two independent genom

SUBMITTER: Rzezniczak TZ 

PROVIDER: S-EPMC9910402 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature