Early-life starvation alters lipid metabolism in adults to cause developmental pathology in Caenorhabditis elegans.

ABSTRACT: Early-life malnutrition increases adult disease risk in humans, but the causal changes in gene regulation, signaling, and metabolism are unclear. In the roundworm Caenorhabditis elegans, early-life starvation causes well-fed larvae to develop germline tumors and other gonad abnormalities as adults. Furthermore, reduced insulin/IGF signaling during larval development suppresses these starvation-induced abnormalities. How early-life starvation and insulin/IGF signaling affect adult pathology is unknown. We show that early-life starvation has pervasive effects on adult gene expression which are largely reversed by reduced insulin/IGF signaling following recovery from starvation. Early-life starvation increases adult fatty-acid synthetase fasn-1 expression in daf-2 insulin/IGF signaling recept

SUBMITTER: Jordan JM 

PROVIDER: S-EPMC9910403 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature