Incident dementia and long-term exposure to constituents of fine particle air pollution: A national cohort study in the United States.

ABSTRACT: Growing evidence suggests that fine particulate matter (PM_2.5) likely increases the risks of dementia, yet little is known about the relative contributions of different constituents. Here, we conducted a nationwide population-based cohort study (2000 to 2017) by integrating the Medicare Chronic Conditions Warehouse database and two independently sourced datasets of high-resolution PM_2.5 major chemical composition, including black carbon (BC), organic matter (OM), nitrate (NO₃^-), sulfate (SO₄^2-), ammonium (NH₄⁺), and soil dust (DUST). To investigate the impact of long-term exposure to PM_2.5 constituents on incident all-cause dementia and Alzheimer's disease (AD), hazard ratios for dementia and

SUBMITTER: Shi L 

PROVIDER: S-EPMC9910468 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature