ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth.

ABSTRACT: The limited efficacy of the current antitumor microenvironment strategies is due in part to the poor understanding of the roles and relative contributions of the various tumor stromal cells to tumor development. Here, we describe a versatile in vivo anthrax toxin protein delivery system allowing for the unambiguous genetic evaluation of individual tumor stromal elements in cancer. Our reengineered tumor-selective anthrax toxin exhibits potent antiproliferative activity by disrupting ERK signaling in sensitive cells. Since this activity requires the surface expression of the capillary morphogenesis protein-2 (CMG2) toxin receptor, genetic manipulation of CMG2 expression using our cell-type-specific CMG2 transgenic mice allows us to specifically define the role of individual tumor stromal ce

SUBMITTER: Zuo Z 

PROVIDER: S-EPMC9910475 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature