FLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis.

ABSTRACT:

Objectives

rs76428106-C, a low frequency polymorphism that affects the splicing of the FLT3 gene, has recently been associated with several seropositive autoimmune diseases. Here, we aimed to evaluate the potential implication of rs76428106-C in the susceptibility to systemic sclerosis (SSc).

Methods

We analysed a total of 26 598 European ancestry individuals, 9063 SSc and 17 535 healthy controls, to test the association between FLT3 rs76428106-C and SSc and its different subphenotypes. Genotype data of rs76428106 were obtained by imputation of already available genome-wide association study data and analysed by logistic regression analysis.

Results

In accordance with that observed in other autoimmune disorders, the FLT3 rs76428106-C allele was significantly increased

SUBMITTER: Martinez-Lopez J 

PROVIDER: S-EPMC9910569 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature