Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex.

ABSTRACT: The convolutions of the mammalian cerebral cortex allow the enlargement of its surface and addition of novel functional areas during evolution while minimizing expansion of the cranium. Cognitive neurodevelopmental disorders in humans, including microcephaly and lissencephaly, are often associated with impaired gyrification. In the classical model of gyrification, surface area is initially set by the number of radial units, and the forces driving cortical folding include neuronal growth, formation of neuropil, glial cell intercalation, and the patterned growth of subcortical white matter. An alternative model proposes that specified neurogenic hotspots in the outer subventricular zone (oSVZ) produce larger numbers of neurons that generate convexities in the cortex. This directly contradict

SUBMITTER: Rash BG 

PROVIDER: S-EPMC9910595 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature