Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction.

ABSTRACT: Breast cancer (BC) is a complex disease comprising multiple distinct subtypes with different genetic features and pathological characteristics. Although a large number of antineoplastic compounds have been approved for clinical use, patient-to-patient variability in drug response is frequently observed, highlighting the need for efficient treatment prediction for individualized therapy. Several patient-derived models have been established lately for the prediction of drug response. However, each of these models has its limitations that impede their clinical application. Here, we report that the whole-tumor cell culture (WTC) ex vivo model could be stably established from all breast tumors with a high success rate (98 out of 116), and it could reassemble the parental tumors with the endogen

SUBMITTER: Chen X 

PROVIDER: S-EPMC9910599 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature