Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis.

ABSTRACT:

Introduction

Gut microbiota can significantly affect the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. Recently, antibiotics were shown to decrease survival rate of patients treated by ICIs. Proton pump inhibitors (PPIs) can indeed modulate microbiota's diversity, therefore altering ICIs response. A meta-analysis was performed based on published data to verify this hypothesis.

Methods

In this study, over 41 publications, exploring the impact of concomitant PPI treatment on outcomes of ICI-treated patients, were analyzed. Evaluated endpoints were overall survival (OS) and progression-free survival (PFS). Pooled hazard ratios (HRs) with a 95% confidence interval (CI) were reported in ICIs in PPI users versus non-PPI users. Subgroup analyses were perf

SUBMITTER: Lopes S 

PROVIDER: S-EPMC9910608 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature