Monitoring of mitochondrial oxygen tension in the operating theatre: An observational study with the novel COMET® monitor

ABSTRACT:

Introduction

The newly introduced Cellular Oxygen METabolism (COMET®) monitor enables the measurement of mitochondrial oxygen tension (mitoPO2) using the protoporphyrin IX triplet state lifetime technique (PpIX-TSLT). This study aims to investigate the feasibility and applicability of the COMET® measurements in the operating theatre and study the behavior of the new parameter mitoPO2 during stable operating conditions.

Methods

In this observational study mitochondrial oxygenation was measured in 20 patients during neurosurgical procedures using the COMET® device. Tissue oxygenation and local blood flow were measured by the Oxygen to See (O2C). Primary outcomes included mitoPO2, skin temperature, mean arterial blood pressure, local blood flow and tissue oxygenation.

Re

SUBMITTER: Harms F 

PROVIDER: S-EPMC9910761 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature