Transiently heritable fates and quorum sensing drive early IFN-I response dynamics.

ABSTRACT: Type I interferon (IFN-I)-mediated antiviral responses are central to host defense against viral infections. Crucial is the tight and well-orchestrated control of cellular decision-making leading to the production of IFN-Is. Innovative single-cell approaches revealed that the initiation of IFN-I production is limited to only fractions of 1-3% of the total population, both found in vitro, in vivo, and across cell types, which were thought to be stochastically regulated. To challenge this dogma, we addressed the influence of various stochastic and deterministic host-intrinsic factors on dictating early IFN-I responses, using a murine fibroblast reporter model. Epigenetic drugs influenced the percentage of responding cells. Next, with the classical Luria-Delbrück fluctuation test, we provided

SUBMITTER: Van Eyndhoven LC 

PROVIDER: S-EPMC9910831 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature