Quantifying the effect of delaying the second COVID-19 vaccine dose in England: a mathematical modelling study.

ABSTRACT:

Background

The UK was the first country to start national COVID-19 vaccination programmes, initially administering doses 3 weeks apart. However, early evidence of high vaccine effectiveness after the first dose and the emergence of the SARS-CoV-2 alpha variant prompted the UK to extend the interval between doses to 12 weeks. In this study, we aimed to quantify the effect of delaying the second vaccine dose in England.

Methods

We used a previously described model of SARS-CoV-2 transmission, calibrated to COVID-19 surveillance data from England, including hospital admissions, hospital occupancy, seroprevalence data, and population-level PCR testing data, using a Bayesian evidence-synthesis framework. We modelled and compared the epidemic trajectory in the counterfactual scenar

SUBMITTER: Imai N 

PROVIDER: S-EPMC9910835 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature