Vaccination-Based Immunoprevention of Colorectal Tumors: A Primer for the Clinician.

ABSTRACT: Colorectal cancer (CRC) continues to be a significant public health problem worldwide. CRC screening programs have reduced the incidence rates of CRCs but still suffer from the problems of missed lesions and interval cancers. Chemopreventive strategies against CRC would benefit high-risk populations but trials testing synthetic and naturally occurring compounds have not yielded a front runner. Immune mechanisms promoting cancer have been modulated to develop immunotherapy for cancer treatment that has revolutionized cancer management, but could also be applied to cancer interception, that is, cancer immunoprevention. Cancer immunoprevention refers to approaches that can enhance the immune system, either directly or by removing natural breaks such as immune checkpoints, to survey and destro

SUBMITTER: Jackson K 

PROVIDER: S-EPMC9911105 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature