BASP1 is a prognostic biomarker associated with immunotherapeutic response in head and neck squamous cell carcinoma.

ABSTRACT:

Backgrounds

Immunotherapy is effective in a subset of head and neck squamous cell carcinoma (HNSCC). However, the unfavorable response rate and inadequate biomarkers for stratifying patients have primarily limited its clinical application. Considering transcriptional factors (TFs) play essential roles in regulating immune activity during HNSCC progression, we comprehensively analyzed the expression alterations of TFs and their prognostic values.

Methods

Gene expression datasets and clinical information of HNSCC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) repository. Then, Brain abundant membrane attached signal protein 1 (BASP1) was screened out of differentially expressed TFs by univariate and multivariate survival analysis. Tumor imm

SUBMITTER: Pan X 

PROVIDER: S-EPMC9911441 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature