The diagnostic value of blood metagenomic next-generation sequencing in patients with acute hematogenous osteomyelitis.

ABSTRACT:

Aims

This study aims to evaluate the diagnostic value of blood metagenomic next-generation sequencing (mNGS) in detecting pathogens from patients clinically diagnosed as acute hematogenous osteomyelitis (AHO).

Methods

This retrospective study enrolled 66 patients with AHO. The test results of mNGS and bacterial culture on different samples, including blood and puncture fluid samples, from patients with AHO were compared to explore the diagnostic value of blood mNGS. Besides, this study also explored the efficacy of blood mNGS in decision making for antibiotic administration and analyzed the factors associated with the positive result of blood mNGS.

Results

The most common causative pathogens were Staphylococcus and Streptococcus. The sensitivity of blood

SUBMITTER: Zhang B 

PROVIDER: S-EPMC9911542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature