Dataset Information

Inter-vendor and inter-observer reliability of diffusion tensor imaging in the musculoskeletal system: a multiscanner MR study.

ABSTRACT:

Background

To evaluate the inter-observer and inter-vendor reliability of diffusion tensor imaging parameters in the musculoskeletal system.

Methods

This prospective study included six healthy volunteers three men (mean age: 42; range: 31-52 years) and three women (mean age: 36; range: 30-44 years). Each subject was scanned using different 3 Tesla magnetic resonance scanners from three different vendors at three different sites bilaterally. First, the intra-class correlation coefficient was used to determine between-observers agreement for overall measurements and clinical sites. Next, between-group comparisons were made through the nonparametric Friedman's test. Finally, the Bland-Altman method was used to determine agreement among the three scanner measurements, comparing them two by two.

Results

A total of 792 measurement were calculated. ICC reported high levels of agreement between the two observers. ICC related to MD, FA, and RD measurements ranged from 0.88 (95% CI 0.85-0.90) to 0.95 (95% CI 0.94-0.96), from 0.85 (95% CI 0.81-0.88) to 0.95 (95% CI 0.93-0.96), and from 0.89 (0.85-0.90) to 0.92 (0.90-0.94). No statistically significant inter-vendor differences were observed. The Bland-Altmann method confirmed a high correlation between parameter values.

Conclusion

An excellent inter-observer and inter-vendor reliability was found in our study.

SUBMITTER: Chianca V

PROVIDER: S-EPMC9911574 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Inter-vendor and inter-observer reliability of diffusion tensor imaging in the musculoskeletal system: a multiscanner MR study.

Chianca Vito V Albano Domenico D Rizzo Stefania S Maas Mario M Sconfienza Luca Maria LM Del Grande Filippo F

Insights into imaging 20230209 1

<h4>Background</h4>To evaluate the inter-observer and inter-vendor reliability of diffusion tensor imaging parameters in the musculoskeletal system.<h4>Methods</h4>This prospective study included six healthy volunteers three men (mean age: 42; range: 31-52 years) and three women (mean age: 36; range: 30-44 years). Each subject was scanned using different 3 Tesla magnetic resonance scanners from three different vendors at three different sites bilaterally. First, the intra-class correlation coeff ...[more]

PMID: 36757529

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Project description:ObjectiveHypoxic-ischemic encephalopathy can lead to lifelong morbidity and premature death in full-term newborns. Here, we aimed to determine the efficacy of diffusion kurtosis (DK) [mean kurtosis (MK)] and diffusion tensor (DT) [fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD), and radial diffusion (RD)] parameters for the early diagnosis of early brain histopathological changes and the prediction of neurodegenerative events in a full-term neonatal hypoxic-ischemic brain injury (HIBD) rat model.MethodsThe HIBD model was generated in postnatal day 7 Sprague-Dawley rats to assess the changes in DK and DT parameters in 10 specific brain structural regions involving the gray matter, white matter, and limbic system during acute (12 h) and subacute (3 d and 5 d) phases after hypoxic ischemia (HI), which were validated against histology. Sensory and cognitive parameters were assessed by the open field, novel object recognition, elevated plus maze, and CatWalk tests.ResultsRepeated-measures ANOVA revealed that specific brain structures showed similar trends to the lesion, and the temporal pattern of MK was substantially more varied than DT parameters, particularly in the deep gray matter. The change rate of MK in the acute phase (12 h) was significantly higher than that of DT parameters. We noted a delayed pseudo-normalization for MK. Additionally, MD, AD, and RD showed more pronounced differences between males and females after HI compared to MK, which was confirmed in behavioral tests. HI females exhibited anxiolytic hyperactivity-like baseline behavior, while the memory ability of HI males was affected in the novel object recognition test. CatWalk assessments revealed chronic deficits in limb gait parameters, particularly the left front paw and right hind paw, as well as poorer performance in HI males than HI females.ConclusionsOur results suggested that DK and DT parameters were complementary in the immature brain and provided great value in assessing early tissue microstructural changes and predicting long-term neurobehavioral deficits, highlighting their ability to detect both acute and long-term changes. Thus, the various diffusion coefficient parameters estimated by the DKI model are powerful tools for early HIBD diagnosis and prognosis assessment, thus providing an experimental and theoretical basis for clinical treatment.

Dataset Information

Inter-vendor and inter-observer reliability of diffusion tensor imaging in the musculoskeletal system: a multiscanner MR study.

Background

Methods

Results

Conclusion

Publications

Inter-vendor and inter-observer reliability of diffusion tensor imaging in the musculoskeletal system: a multiscanner MR study.

Similar Datasets

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