Investigation of image-based lesion and kidney dosimetry protocols for ¹⁷⁷Lu-PSMA-I&T therapy with and without a late SPECT/CT acquisition.

ABSTRACT:

Background

¹⁷⁷Lu-PSMA therapy has been successfully used to prolong the survival of patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry based on serial quantitative SPECT/CT imaging can support the understanding of dose-effect relationships. However, multiple SPECT/CT measurements can be challenging for patients, which motivates the investigation of efficient sampling schedules and their impact on dosimetry. In this study, different time samplings with respect to the number and timing of SPECT/CT acquisitions with and without a late measurement were investigated.

Materials and methods

In total, 43 lesions and 10 kidneys of 5 patients receiving ¹⁷⁷Lu-PSMA-I&T therapy were investigated. Whole-body SPECT/CT measurement

SUBMITTER: Resch S 

PROVIDER: S-EPMC9911578 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature