Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2.

ABSTRACT: The dopamine D₄ receptor (D₄R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D₄R has also been investigated as a target for antipsychotics due to its high affinity for clozapine. As opposed to the closely related dopamine D₂ receptor (D₂R), dopamine-induced arrestin recruitment and desensitization at the D₄R have not been studied in detail. Indeed, some earlier investigations could not detect arrestin recruitment and desensitization of this receptor upon its activation by agonist. Here, we used a novel nanoluciferase complementation assay to study dopamine-induced recrui

SUBMITTER: Burstrom V 

PROVIDER: S-EPMC9911804 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature